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Volume 21 , Issue 1
January/February 2001
Pages 41-47

Effect on Bone Healing of Bone Morphogenetic Protein Placed in Combination with Endosseous Implants: A Pilot Study in Beagle Dogs

Joseph P. Fiorellini, DMD, DMSc, Daniel Buser, Prof Dr Med Dent, Erin Riley, DMD, T. Howard Howell, DDS

PMID: 11829034
DOI: 10.11607/prd.00.0396

Although dental implants have become an effective treatment modality for the replacement of missing teeth, their predictability relies on successful osseointegration during the healing period. The purpose of this pilot study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on early bone formation within the perforations of dental implants in beagle dogs. Histologic sections were evaluated for the extent of new bone formation within a 1-mm diameter of through-and-through perforations. Data indicated that significantly more bone formation occurred with rhBMP-2–treated sites within the implant perforation (P < 0.01) compared to sites treated with the vehicle alone. This pilot study indicates that rhBMP-2 increases the rate and extent of bone formation in combination with dental implants. (Int J Periodontics Restorative Dent 2001;21:41–47.)

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